How Keeping Glutathione Levels Up Can Benefit Your Health & Your Vitamin D Status GrassrootsHealth Glutathione is a critical soldier in our line of defense. We even have mechanisms that recycle and reuse it. But what happens when our toxic burden becomes too high? Our genetic detoxification Glutathione Renue By Science Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.